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Citation: Aron N, Sen S, Khokhar S. Comment on “Comparison of 45-degree Kelman and
45-degree balanced phaco tip designs in torsional microcoaxial
phacoemulsification”. Int J Ophthalmol 2017; 10(8):1334-1336
Comment on “Comparison of 45-degree Kelman and
45-degree balanced phaco tip designs in torsional microcoaxial
phacoemulsification”
Neelima Aron, Sagnik Sen, Sudarshan Khokhar
Department
of Ophthalmology, Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India
Institute of Medical Sciences, New Delhi 110029, India
Correspondence
to: Sudarshan Khokhar. Cataract and Refractive Surgery Services, Dr.
Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical
Sciences, New Delhi 110029, India. skhokhar38@yahoo.com
Received:
2016-09-08
Accepted: 2017-06-29
DOI:10.18240/ijo.2017.08.25
Citation: Aron N, Sen S, Khokhar S. Comment on “Comparison of 45-degree Kelman and
45-degree balanced phaco tip designs in torsional microcoaxial
phacoemulsification”. Int J Ophthalmol 2017; 10(8):1334-1336
Dear
Editor,
We
read with interest the article “Comparison of 45-degree Kelman and 45-degree
balanced phaco tip designs in torsional microcoaxial phacoemulsification” by
Demircan et al[1]. The authors describe the
intraoperative and post-operative outcomes of phacoemulsification in terms of
cumulative dissipated energy (CDE), total ultrasound (US) time, torsional US
time, total fluid use, percentage change in central corneal thickness and
endothelial cell count in the two groups. A comparative evaluation has been
made between the two groups involving the Kelman mini-flared tip and the
Intrepid balanced phaco tip using the Infiniti Ozil IP Vision system (Alcon
Laboratories Inc., Fort Worth, TX, USA) as has been explicitly mentioned in the
article under the “Methods” section. However, we would like to highlight the
fact that the Intrepid balanced phacoemulsification tip has been designed to be
used only with the Centurion Vision System (Alcon Laboratories Inc., Fort
Worth, TX, USA) and not with the Infiniti System. In fact, one of the major
mechanisms of energy reduction with the Centurion System is enhancement of
torsional US efficiency through this redesigned tip as has been reported in
many studies[2-4]. Previous reports also make a
comparative evaluation of the two tips, but either on the two different
phacoemulsification machines or solely on the Centurion System[2-3]. Hence, it will be useful to clarify about the
conditions of usage of the two tips to avoid any confusion to the readers.
Furthermore,
a higher amplitude value of the balanced tip has been implicated as a factor
for higher energy produced and a greater turbulence caused in the anterior
chamber as compared to the Kelman tip which has been reflected in the
percentage endothelial cell loss and change in central corneal thickness in the
first week post-operatively[1]. However, these
results are not reflected in the CDE values which is the total energy produced
by the process of phacoemulsification within a closed system. Further, the
other intraoperative parameters are also more favourable towards the balanced
tip than the Kelman tip. With all intraoperative US parameters pointing towards
a higher efficiency of the balanced tip, a relatively worse post-operative
outcomes raise questions about the presence of any other confounding factors
affecting the results in these two groups.
According
to the analysis done for various variables in this study, it has been seen that
for many parameters such as CDE, total US time and torsional US time, the
standard deviation values are more than half of the mean. In such a situation,
the standard deviation values become meaningless. It is an indication that the
data deviates substantially from a normal Gaussian distribution of a bell
shaped curve and almost always points towards a skewed distribution affecting
the accurate comparison between the two sets of data. Typically in such cases,
the standard deviation values should preferably not be reported. The
recommendation is to use the range (minimum and maximum value) or the
interquartile range (25th percentile and 75th percentile)
instead of standard deviation. Furthermore, it is preferred to use a
non-parametric test while applying the statistical test for such variables.
Hence, a further look into the analysis of data in the study would be highly
appreciated.
We
hope our analysis adds value to the discussion of the article and await the
author’s response.
Conflicts
of Interest: Aron N, None; Sen S, None; Khokhar S, None.
1 Demircan S, Ataş M, Göktaş E, Başkan B. Comparison
of 45-degree Kelman and 45-degree balanced phaco tip designs in torsional
microcoaxial phacoemulsification. Int J
Ophthalmol 2015;8(6):1168-1172. [PMC free article]
[PubMed]
2 Chen M, Anderson E, Hill G, Chen JJ, Patrianakos T.
Comparison of cumulative dissipated energy between the Infiniti and Centurion
phacoemulsification systems. Clin
Ophthalmol 2015;9:1367-1372. [CrossRef]
[PMC free
article] [PubMed]
3 Yoo A, Nam KY, Tchah H, Kim MJ. Heat generation and efficiency
of a new modified phaco tip and sleeve. PLoS
One 2016;11(8):e0159049. [CrossRef] [PMC free article]
[PubMed]
4
Tjia KF. Novel balanced phaco tip for microcoaxial torsional phaco. Paper
presented at: The ASCRS meeting; April 27, 2014; Boston, MA, USA.
Dear
Editor,
We
thank Aron et al for their comments relating to comparative evaluation of Kelman and
balanced phaco tip in phacoemulsification. Our study differ from prior studies
that compared efficiency of the two tips either on the between Infiniti and
Centurion system or only on Centurion system. In this study an Ozil handpiece
with either a 0.9 mm 45-degree beveled
miniflared Kelman tip or a 0.9 mm 45-degree beveled Intrepid balanced tip were used in the
Infiniti Phacoemulsification System[1].
Chen
et al[2] compared Infiniti and Centurion
Phacoemulsification System. They found that an adjusted average energy
reduction of 38% when using the Centurion System. The Intrepid balanced mini
tip’s design enables approximately 50% more lateral movement and transfer
energy to its distal end compared to miniflared Kelman tip. As Aron et al
mentioned that with all intraoperative ultrasound parameters pointing towards a
higher efficiency of the balanced tip, a relatively worse postoperative
outcomes raise questions about the presence of any other confounding factors
affecting the results in these two groups. It is explained that the Intrepid balanced
phacoemulsification tip has been designed to be used only with the Centurion
Vision System (Alcon Laboratories Inc., Fort Worth, TX, USA) and not with the
Infiniti System. Another confounding factor may be improvement in active
fluidics technology that is designed to significantly reduce occlusion break
surge and ensure stability of the anterior chamber, even at high vacuum
settings in the Centurion Vision
System (Alcon Laboratories Inc., Fort Worth, TX, USA)[3-4].
We
repeated statistical analysis with a non-parametric test (Mann Withney U
test). As seen Table 1, there were no significant differences between two tests
for any variables.
Table 1
Comparison of patient characteristics and intraoperative parameters
Variables |
Kelman (n=58) |
Balanced (n=58) |
P |
Age (a) |
67.00±8.95 |
68.40±10.04 |
0.459 |
Gender
(F/M) |
25
(43.1)/33 (56.9) |
26
(44.8)/32 (55.2) |
0.825 |
Eye
(right/left) |
31
(53.4)/27 (46.6) |
29
(50.0)/29 (50.0) |
0.662 |
Anterior
chamber depth (mm) |
3.19±0.34 |
3.11±0.37 |
0.336 |
Pupil size
(mm) |
7.76±1.43 |
7.72±1.51 |
0.885 |
Total
ultrasound time (s) |
12.50
(0.08-60.00) |
7.95
(0.00-46.10) |
0.017 |
Torsional
ultrasound time (s) |
12.20
(0.08-58.20) |
7.65
(0.00-45.00) |
0.015 |
Cumulative
dissipated energy |
4.80
(0.26-22.21) |
2.78
(0.00-16.13) |
0.012 |
Estimated
fluid use (mL) |
45.50
(23.00-99.00) |
41.50
(18.00-81.00) |
0.048 |
Values are expressed as n (%),
mean±SD, or median (minimum-maximum).
We
hope we clarified the points related to Dr. Aron et al's comments and
again thank them for the valuable contribution.
1 Demircan S, Ataş M, Göktaş E, Başkan B. Comparison
of 45-degree Kelman and 45-degree balanced phaco tip designs in torsional microcoaxial
phacoemulsification. Int J Ophthalmol
2015;8(6):1168-1172. [PMC free article]
[PubMed]
2 Chen M, Anderson E, Hill G, Chen JJ, Patrianakos T.
Comparison of cumulative dissipated energy between the Infiniti and Centurion
phacoemulsification systems. Clin
Ophthalmol 2015;9:1367-1372. [CrossRef]
[PMC free
article] [PubMed]
3 Tjia KF. Removing dense cataract with the CENTURION Vision
System: demonstrating technological advances. Cataract & Refractive Surgery Today October 2014.
4
Tjia KF. Novel balanced phaco tip for microcoaxial torsional phaco. Paper
presented at: The ASCRS meeting; April 27, 2014; Boston, MA, USA.
Suleyman
Demircan, Mustafa Ataş
Eye
Clinic, Kayseri Training and Research Hospital, Kayseri 38010, Turkey
Dear
Editor,
We
thank Demircan et al[1] for their response
to our comments on the article published in your esteemed journal titled
“Comparison of 45-degree Kelman and 45-degree balanced phaco tip designs in
torsional microcoaxial phacoemulsification”. We appreciate them for having
repeated the statistical analysis with non-parametric tests achieving similar
results without a change in the final outcome of their study. Further, we agree
with their results that a higher endothelial cell loss and a greater central
corneal thickness in the first post-operative week with the balanced tip may be
seen due to the greater amplitude of excursion of the balanced tip leading to a
higher energy production. However, few questions still remain unanswered. The
new Intrepid balanced phaco tip has been specifically designed to be used with
the Centurion Vision System (Alcon Laboratories Inc., Fort Worth, TX, USA). The
authors, however, used the balanced tip with the Infiniti Ozil IP Vision System
(Alcon Laboratories Inc., Fort Worth, TX, USA). Both the Infiniti and the
Centurion Vision systems work on different fluidic mechanisms (gravity based
fluidics in Infiniti vs active fluidics in Centurion System). Whether
the balanced tip works with a similar efficiency with the Infiniti System based
on entirely different fluidics is questionable.
We
hope to get the author’s response to this query that might add value to the
discussion of the article.
1 Demircan S, Ataş M, Göktaş E, Başkan B. Comparison
of 45-degree Kelman and 45-degree balanced phaco tip designs in torsional
microcoaxial phacoemulsification. Int J
Ophthalmol 2015;8(6):1168-1172. [PMC free article]
[PubMed]
Neelima
Aron, Sagnik Sen, Sudarshan Khokhar
Department
of Ophthalmology, Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India
Institute of Medical Sciences, New Delhi 110029, India
Dear
Editor,
We
thank Aron et al for their reply to our response relating to comment on comparative
evaluation of Kelman and balanced phaco tip in phacoemulsification[1]. They want to know that the new Intrepid balanced
phaco tip has been specifically designed to be used with the Centurion Vision
System (Alcon Laboratories Inc., Fort Worth, TX, USA). The authors, however,
used the balanced tip with the Infiniti Ozil IP Vision System (Alcon
Laboratories Inc., Fort Worth, TX, USA). Both the Infiniti and the Centurion
Vision Systems work on different fluidic mechanisms (gravity based fluidics in
Infiniti vs active fluidics in Centurion System). Whether the balanced
tip works with a similar efficiency with the Infiniti System based on entirely
different fluidics is questionable.
Both
the Infiniti Vision System and the Centurion Vision System use peristaltic
pumps to control aspiration. Similar to other gravity-based phacoemulsification
aspiration systems, the Infiniti uses a bottle of balanced salt solution
suspended by an adjustable pole with gravity supplying the infusion pressure.
The Centurion can operate in 1 of 2 infusion modes; that is, using gravity as a
passive force or using an active system that compresses a compliant, balanced
salt solution-filled bag between motorized plates. The actively controlled
system applies or releases bag pressure in response to varying irrigation
pressure at the cassette to maintain a target intraocular pressare (IOP) during
surgery despite varying aspiration flow rates. Nicoli et al[2] compared these 3 configurations in laboratory study.
They concluded that two passive or gravity-based fluidics systems showed
predictable decreases in IOP with increasing aspiration flow rates, whereas an
active fluidics phacoemulsification system that regulated fluid flow by
applying pressure to a compliant irrigation reservoir maintained target IOPs
across zero-flow and active-flow conditions. Actively controlled fluidics
systems should improve anterior chamber stability during phacoemulsification
cataract surgery. In another study, Solomon et al[3]
compared that the active-fluidics configuration and the gravity-fluidics configuration.
They found that the cumulative dissipated energy (CDE) was significantly lower
with the active-fluidics configuration than with the gravity-fluidics
configuration. Together, these findings suggest that the active-fluidics
configuration achieved greater surgical efficiency than the gravity-fluidics
configuration. On the other hand They used different phaco tips and sleeves
between the active fluidics and gravity-fluidics configurations. These
variables might have contributed to the observed differences in surgical
efficiency between the Centurion Vision System and Infiniti Vision System phaco
systems. Because the 45-degree Intrepid balanced tip used on the Centurion is
more efficient when removing nuclear material than the 45-degree mini-flared tip.
This is shown by the manufacturer’s recommendation to use lower power settings
for the balanced tip than for mini-flared tips[4].
They assessed these configurations because they represented the most commonly
used configurations for the 2 systems; nevertheless, further evaluation using
the same tip and sleeve for each phaco system would enable more direct
assessment of efficiency differences between the 2 systems. Furthermore,
because the Centurion Vision System was newly introduced at the time of their study,
recommended settings for the overall community of ophthalmic surgeons had not
yet been optimized. Although performing more previous surgeries provided
surgeons with adequate experience with the Centurion Vision System, the lack of
longer experience and ideal predetermined settings was a challenge. With
similar reasons, in our study, we only evaulated efficiency of balanced tip
compared with Kelman tip in the gravity based fluidics on the Infiniti Vision
System. Because the Centurion Vision System has both fluidics systems.
In
conclusion, Packard[5] emphasized that unless
both tips are used on both machines so that the fluidics of each can be
compared independently.
We
hope we clarified the points related to
Dr. Aron et al's reply to our response for comment and again
thank them for the valuable contribution.
1 Demircan S, Ataş M, Göktaş E, Başkan B. Comparison of 45-degree
Kelman and 45-degree balanced phaco tip designs in torsional microcoaxial
phacoemulsification. Int J Ophthalmol
2015;8(6):1168-1172. [PMC free article]
[PubMed]
2 Nicoli CM, Dimalanta R, Miller KM. Experimental
anterior chamber maintenance in active versus passive phacoemulsification
fluidics systems. J Cataract Refract Surg
2016;42(1):157-162. [CrossRef]
[PubMed]
3 Solomon KD, Lorente R, Fanney D, Cionni RJ. Clinical
study using a new phacoemulsification system with surgical intraocular pressure
control. J Cataract Refract Surg
2016;42(4):542-549. [CrossRef]
[PubMed]
4 Alcon CenturionTM
Vision System Council Meeting 2014. Sunday 12th October, Milan Italy. EuroTimes
February Supplement, 2015. Available at:
https://issuu.com/eurotimes/docs/20-2_alcon-supplement. Accessed on July 24,
2016.
5 Packard R. Confusion about the importance of phaco
tip configuration in comparing machine performance. J Cataract Refract Surg 2016;42(9):1391. [CrossRef] [PubMed]
Suleyman
Demircan, Mustafa Ataş
Eye
Clinic, Kayseri Training and Research Hospital, Kayseri 38010, Turkey