AIM: To investigate the surgery method in the treatment, prevention of recurrence of pterygium. METHODS:Mitomycin C combined with limbal stem cell transplantation was used in 399 cases 469 eyes with pterygium on the basis of excision. RESULTS: Of the 399 cases 469 eyes, 456 eyes had no recurrence, only 13 eyes had recurrence. Recurrence rate was 2.8%. CONCLUSION: Limbal stem cell transplantation combined with mitomycin C for pterygium is an effective surgical method in preventing the recurrence of pterygium and worth promoting.