·AIM:To observe the changes of early retrospective clinical study between aspherical oblation excimer laser in situ keratomileusis(A-LASIK),the wavefront-guided laser in situ keratomileusis(W-LASIK)and the standard laser in situ keratomileusis(S-LASIK)for treatment of myopia and provide the directions to selecte individuation surgery for the different diopters of spherical refractive,and to compare and analyze the safety and efficiency of A-LASIK,W-LASIKand W-LASIK for treatment of myopia.·METHODS:Two hundreds and sixty-eight eyes of 136 cases myopia were enrolled and presented into three groups according to their diopters of spherical refractive error(low:<-3.00D;middle:-3.00>-<-6.00D;high:-6.00>-<-9.00D).The cases in each group were subdivided into three groups again according to their surgery method:A-LASIK,W-LASIK and S-LASIK.Topography which visual acuity,diopter,offer Q value,high order aberration refraction,also postoperative glare were noted.The ablation zone was from 6.0 to 7.0mm.Wavefront aberrations were analyzed for 6.0mm pupil zone.Refraction were observed before and 1,3 and 6 months after surgery.To compare and analyze the changes and relationships of index.·RESULTS:At the 6 months after surgery,A-LASIK group and W-LASIK showed the better acception than S-LASIK group,difference was statistical significant(P<0.05).In middle group,the visual acuity of W-LASIK was better than the others,and the difference was statisticaly significant(P<0.05).In midlle group,the asphericity of A-LASIK group was the more decreased obviously than W-LASIK group and S-LASIK group,the coma was increased in W-LASIK and spherical aberration was decreased obviously in A-LASIK,and the difference was statisticaly significant(P<0.01).·CONCLUSION:A-LASIK,W-LASIK and S-LASIK are effective on correcting myopia and astigmatism safely and effectivly.A-LASIK and W-LASIK show the better acuity at night.A-LASIK can degrade the spherical aberration after surgery in low group and high group,especially in middle group.W-LASIK can elevate the acuity of vision postoperativly in middle group and decrease RMS of anterior corneal coma in middle group and high group markedly.It is a good choice to raise acuity by A-LASIK and W-LASIK.·