AIM:To study the therapic effect of drainage Fel Ursi (DFU) on retinal oxidative damage in strepfozocin-induced diabetic rats.·METHODS: The changes of body weight, blood glucose, retinal ultrastructure, SOD and MDA among the normal SD rats,diabetic rats and diabetic rats therapied by DFU were compared. ·RESULTS: There were mitochondrion changes, cell degeneration and apoptosis of retinal neurones and neuroglia cells in the diabetic rats retina. Compared with the control group, the SOD decreased significantly (P<0.05), the MDA increased significantly(P<0.05). However, the body weight and blood glucose had the same changes between the therapic group and diabetic rats group. ·CONCLUSION: DFU can relieve the retinal cells mito-chondrion pathological changes, prevent the cells apopto-sis, block up the process of the pathological changes of the retinal blood vessel.