AIM:To evaluate whether the disc damage likelihood scale(DDLS)graded by the map of heidelberg retina tomography(HRT) is correlated with the structural and functional change in optic nerve with primary open angle glaucoma(POAG).METHODS: Consecutive observational case series of 60 eyes 60 patients with POAG were enrolled in the study. HRT-Ⅲ examination was performed by an examiner masked to the clinical examination findings. While all eyes were detected by OCTOPUS -900 visual field perimetry (G2-TOP). Rim area(RA) and mean defect(MD)were recorded. The DDLS score were graded by topographic and reflective map of HRT-Ⅲ. Findings were assessed by the Pearsons.RESULTS: Eleven eyes with optic discs of 3.09 to 3.43mm2,36 eyes with optic discs of 2.41 to 2.67mm2 and 13 eyes with optic discs of 1.64 to 1.81 mm2 were analyzed. The results showed that DDLS was strongly correlated with RA and MD,and the correlation between DDLS and MD did not change obviously along with magnification of optic disc area.CONCLUSION: The DDLS graded by the map of HRT is a good method to grade the change of structural and function in optic nerve with POAG.