AIM:To evaluate the feasibility and efficacy in lysis of posterior synechia by 532 laser combined with Nd∶YAG laser.METHODS: Ninety-seven patients 116 eyes of posterior synechia were divided into three groups: Nd∶YAG laser group, 532 laser group and combined both group. Three kinds of method in order to loosen posterior synechia.RESULTS: Synechia in 116 eyes were dissolved by laser,the pupil diameter ≥ 6mm (n=92 ) accounted for 79.3%; 5-6mm (n=24) accounted for 20.7%. All the pupil adhesions were dissolved accounting for 74.1% (n=86); most of the pupil adhesions were dissolved in 30 eyes accounting for 25.9%. Nd∶YAG laser group (n=18): pupl diameter ≥6mm in postoperation was in 12 eyes accounted for 66.7%, 5-6mm was in 6 eyes accounted for 33.3%; 532 laser group(n= 61): the pupil diameter ≥6mm in postoperation was in 52 eyes accounted for 85.2%, 5-6mm was in 9 eyes accounted for 14.8%; 532 laser combined with Nd∶YAG laser group (n=37) : pupil diameter ≥6mm in postoperation was in 33 eyes accounted for 89.2%, 5-6mm was in 4 eyes accounted for 10.8%.CONCLUSION: Laser lysis is a safe and effective method for posterior synechia.