AIM:To explore the application effect of the integration of problem-based learning (PBL) with case-based learning (CBL) teaching method in ophthalmology nursing teaching. ·METHODS:Totally 105 nursing students of two classes in grade 2007 were randomized into two groups:experimental group (n=55)and control group(n=50). The integration of PBL with CBL teaching method was used in the experimental group and the traditional teaching method was used in the control group. ·RESULTS:There were significant differences between the experimental group and the control group in the actors including the scores of the theory tests,the degree of students’ satisfaction and the excellence rate of the teachers(P<0.01),·CONCLUSION:The integration of PBL with CBL teaching method is benefit for the cultivation of the students’ comprehensive quality,which is better than the traditional teaching method.