·AIM:To assess the protective effect of Erigeron breviscapus extraction on retinal ganglion cells under high intraocular pressure.·METHODS:Totally 40 cats were randomly divided into four groups,control,model,Erigeron breviscapus and cranial nerve growthine group,10 cats in each group.All of cats were injected 20g/L Methyl cellulose into anterior chamber to make cat model with acute high intraocular pressure,then,forelimb vein medicine administration was started respectively according to every experimental group from the first day after model completed,once a day,9 days continuously.At the end,the changes of multifocal electroretinogram(mfERG)were observed before and after treatment.·RESULTS:The first order reaction of mfERG had significant changes in cats with high intraocular pressure,mainly as follows:the total reaction density of wave P1 decreased and the P1 reflect density of each ring in concentric rings were less than that of preoperative,and the peak latency of the third ring prolonged.All above of mfERG showed high intraocular pressure damaged to the visual function.After treatment with Erigeron breviscapus extraction for 9 days,the mfERG was obviously improved.·CONCLUSION:It be manifested as:the wave N1 amplitude density of the second and third ring increased compared with model group and pre-medication,the wave P1 amplitude density of total ring and the first,second,third and fourth of concentric rings increased significantly,the wave P1 peak latency of the third concentric ring shorted obviously.Conclusion:Erigeron breviscapus extraction could improve wave N1 and P1 amplitude density and shorten wave P1 peak latency in the first order reaction.It illustrates that the extraction of breviscapus can protect and improve the ocular function under high intraocular pressure.·