·AIM:To investigate the influences of wavefront guided techniques on the higher-order aberrations after laser-assisted subepithelial keratectomy(LASEK)surgery.·METHODS:Totally 40 patients 80 eyes,whose root mean square(RMS)values were over 0.3,not for LASIK,were randomly divided into two groups.One group 20 patients 40 eyes were applied conventional LASEK with Planoscan,the other 20 patients 40 eyes were applied wavefront guided LASEK with Zyoptix.Total corneal,coma and spherical aberration values were measured by Zywave aberrometer preoperatively and 1 month and 3 months postoperatively for all eyes.·RESULTS:There was no significant difference in higher-order aberrations,trefoil aberrations and spherical aberrations before surgery(P>0.05).RMS value of high order aberrations with 6mm pupil increased compared with that before surgery.There was significant difference in higher-order aberrations,trefoil aberrations and spherical aberrations between two groups(P<0.05).In postoperative month 3,two groups had lower RMS values of coma and trefoil aberrations than in month 1,whereas Zyoptix LASEK had lower higher-order aberrations than Planoscan LASEK.·CONCLUSION:Wavefront guided LASEK had better results than LASEK with Planoscan in higher-order aberration changes.·