·AIM:To evaluate the effect of comprehensive treatment for old children and juvenile with serious anisometropia amblyopia.·METHODS:Fifty-six old children and juvenile with serious anisometropia amblyopia were divided into two groups.Group A(30 patients)wore rigid gas permeable(RCP)lenses and group B patients wore eyeglass frames.Both groups received same amblyopia therapy with a patch,visual stimulation therapy,antisuppression therapy.Anisometropia amblyopia old children and juvenile were added binocularity therapy and stereopsis therapy while their corrected acuity ≥4.7.The effects of the treatment methods were compared.·RESULTS:The effective rate of both groups with serious anisometropia amblyopia were 100%.After 24 months,group A had cure rate of 33%,while group B only had cure rate of 8%.The cure rate differed significantly between two groups.Antisuppress rate of group A was 37%,antisuppress rate of group B was 4%,The cure rate differed significantly between two groups.The rate of group A which had stereo vision acuity ≤100" was 30%,the rate of group B was 4%.No conditions such as corneal abrasion or conjunctival congestion occurred,and there were none of the problems that occurred with spectacle lenses treatment.·CONCLUSION:The effective rate of both groups with serious anisometropia amblyopia are 100%.After 24 months,group A is better than group B in cure rate,antisuppress rate and stereo vision acuity.The result differed significantly between two groups.·