·AIM:To analyze cutting thickness on TOSCA treatment of complex refractive errors.·METHODS:Totally 42 eyes 23 patients who received TOSCA were selected in our hospital,they were complex refractive errors.The spherical equivalent degree was-2.50--13.50D with an average of-7.51±2.23D.Then the cutting thickness in TOSCA and LASIK/LASEK mode was compared.·RESULTS:The preoperative average UCVA was 0.11±0.19 and BCVA was 0.98±0.16,and at 6 months postoperatively the average UCVA was 1.03±0.30,it was significantly improved and statisticaly different compared with the preoperative UCVA(P<0.05),and it was not significantly different compared with the preoperative BSCVA(P>0.05).The preoperative average spherical equivalent was-7.51±2.23D,and at 6 months postoperatively the average spherical equivalent was-0.42± 0.67D,controlled within±0.50D to achieve the purpose of correction of myopia.The preoperative average cutting thickness and the remaining thickness respectively were 92.43±21.28μm and 409.17±25.47μm in TOSCA mode,and 123.26±28.73μm,378.69±32.65μm in LASIK/LASEK,it was statistically different(P<0.05).·CONCLUSION:TOSCA can save corneal thickness significantly on treatment of complex refractive compared with LASIK,and improve the safety of operation theoretically.·