·AIM:To observe the clinical effectiveness of two-hand phacoemulsification cataract surgery for age-related cataract.·METHODS:Totally 42 patients 42 eyes with age-related cataract underwent two-hand phacoemulsification cataract surgery using the Legacy 20000(Alcon Inc.U.S.)by the same surgeon.Vision before and after surgery,intraocular pressure(IOP),corneal astigmatism and the change of corneal endothelial cell,and postoperative complications were observed.·RESULTS:The best-corrected visual acuity was 0.67±0.11,0.81±0.14,0.83±0.12 in postoperative day 1,week 1,month 3,respectively,and they were significantly increased compared with baseline(P<0.01);The average IOP were 12.44±4.70mmHg,13.56±3.20mmHg,12.90±2.00mmHg in postoperative day 1,week 1,month 3,and there were no statistical differences compared with preoperative(P>0.05);The average corneal astigmatism were 1.23±0.62D,0.97±0.53D,(P<0.01,P<0.05)in postoperative day 1 and week 1 and they were significantly increased compared with baseline(P<0.01),whereas there were no statistically differences in postoperative month 3(0.65±0.47D,P=0.24).In postoperative month 3 corneal endothelial density was 2235.06±418.43/mm2,and the loss rate of corneal endothelial cell was(11.90±7.32)%.All patients were without serious complications postoperatively.·CONCLUSION:Two-hand micro-incision for age-related cataract is a safe and effective method.·