·AIM:To observe the clinical effect of probing of lacrimal passage for neonatal dacryocystitis.·METHODS:Totally 1856 patients(2217 eyes)of neonatal dacryocystitis without syphilis of lacrimal passages underwent the probing of lacrimal passage,syphilis of lacrimal passages of 2 days with 1 time/d postoperative.Tobramycin gutta of 1 week with 3 time/d postoperative.The following time was 6-12 months.·RESULTS:Totally 2143 eyes were probed for 1 time,62 eyes were probed for 2 times,12 eyes were probed for 3 times.The cure rate was 99.59%(2208/2217).·CONCLUSION:The probing of lacrimal passage is safe,reliable and has good effect for neonatal dacryocystitis.2-6 months was the best probing time.·