·AIM:To discuss the treatment procedure and system symptom of ocular chemical injury by acute mixed toxic gas poisoning,and to analyse its clinical experience.·METHODS:All patients with ocular chemical injury as the main clinical manifestations,underwent integrated treatment focused with acute ocular injury.·RESULTS:Totally 22 patient were corneal transparency and visual acuity from 0.8 to 1.2 were in 11 patients.Sense of smell and taste loss were in 6 patients.Toxic brain injury and aplastic anemia were in 1 patient.·CONCLUSION:The mixture of toxic gas can cause acute ocular chemical burns,especial in the ocular surface damage.Anti-infective and repairment of ocular surface treatment were important and systemic treatment can not be ignored.No obvious damage was in visual function.·