·AIM:To investigate avastin eyedrops and subconjunctival injection of avastin on corneal neovascularization(CNV)induced by corneal alkali burns(CAB)in SD rats.METHODS:Single eye corneal alkali burn model was established in 60 SD rats.The rats were divided into 3 groups randomly.Group A(control group),group B(avastin eyedrops group)and group C(subconjunctival injection of avastin group),20 rats in each group.The occurrence and development of CNV were observed termly by slit lamp microscope on the 3th,5th,7th,14th day after corneal alkali burn,and the area of CNV was calculated by computer image analysis.Then five rats of each group were killed on the 3th,5th,7th,14th day after corneal alkali burn,and the corneas were taken for Immunohistochemistry technique to detect VEGFR-2,and immunofluorescence examination to detect CD31.RESULTS:The CNV areas of group B,C was smaller than group A(P<0.01),however there is no significant difference between B and C in terms of CNV areas(P>0.01).The level of VEGFR-2 and CD31 expression in group B,C was lower than group A(P<0.01),however there is no significant difference between B and C(P>0.01).CONCLUSION:Avastin eyedrops and subconjunctival injection of avastin can effectively inhibit CNV after alkali burns.