·AIM:To observe the efficacy and safety of oral anti-inflammatory drug pudilan for epidemic keratoconjunctivitis.METHODS:A total of 120 cases 226 eyes with epidemic keratoconjunctivitis were randomly divided into test group and control group,60 cases in each group.The test group was treated with pudilan oral liquid and diclofenac sodium eye drops;the control group received diclofenac sodium eye drops,for 14 days as a total course of treatment.Clinical efficacy and safety were observed after treatment.RESULTS:In the test group and control group,the total clinical effective rates were 90.0% and 75.0%,the cure rates were 85.0% and 68.3% respectively,the difference was statistically significant(P<0.05).The test group and control group had no significant adverse reactions.CONCLUSION:Compared with simple use of diclofenac sodium eye drops,pudilan oral liquid combined with diclofenac sodium eye drops has exact clinical curative effect and no adverse reaction in treatment of epidemic keratoconjunctivitis.