·AIM:To evaluate the efficacy and safety of intravitreal Bevacizumab(IVB)combined with retinal photoco-agulation for iris and retinal neovascularization.METHODS:The clinical data of 13 patients 13 eyes with iris or retinal neovascularization treated with IVB associated with retinal photocoagulation were retrospectively analyzed.Among these patients,retinal neovascularization was secondary to branch retinal vein occlusion(BRVO)in 2 eyes,to proliferative diabetic retinopathy(PDR)in 6 eyes and to Eales disease in 1 eye.4 eyes with iris and retinal neovascularization were secondary to central retinal vein occlusion.All of patients underwent IVB(1.25mg/0.05mL)combined with retinal photocoagulation.The follow-up period ranged from 3 to 18 months.Additional IVB and retinal photocoagulation were administered if recurrence was observed in follow-up period.The changes of best-corrected visual acuity(BCVA),intraocular pressure(IOP),fundus fluorescein angiography(FFA)were observed and analyzed before and after the treatment.RESULTS:At the end of the follow-up period,BCVA was improved obviously(>1 lines)in 8 eyes(61.5%),kept stable(changed within 1 line)in 4 eyes(30.8%)and decreased(>1 lines)in one eye(7.7%).The regression of iris and retinal neovascularization in all 13 eyes were observed by FFA image.There were 2 eyes with additional IVB and retinal photocoagulation during follow-up period.Among neovascular glaucoma,decreased IOP was noticed in 2 eyes(50.0%).The only complication was subconjunctival hemorrhage in one eye.CONCLUSION:The preliminary result in our observation shows that IVB combined with retinal photocoagulation is effective and safe in treating iris and retinal neovascularization.This should be comfirmed by a multicenter,randomized,controlled clinical trial.