AIM:To compare one-site vs two-site phacotrabe-culectomy in chronic angle-closure glaucoma(CACG)coexisting with cataract.METHODS:This prospective,randomized study included 41 eyes with CACG.One-site approach was performed in 21 eyes and two-site procedure in 20 eyes.Intraocular pressure(IOP),best-corrected visual acuity(BCVA),the number of antiglaucoma medications and complications were observed.All patients were followed up for 9 months.RESULTS:There were no significant differences between the two groups preoperatively.IOP decreased from 22.7±4.9mmHg and 23.7±4.7mmHg preoperatively in one-and two-site groups to 18.0±1.2mmHg and 16.7±1.1mmHg 9 months after operation respectively(P<0.05).There were no significant differences in mean IOP between the two groups at any time(P>0.05).Decrease of the number of antiglaucoma medications and BCVA improvement were similar in both groups 9 months after surgery(P>0.05).There were no significant differences in complications between the two surgical procedures.CONCLUSION:There were no significant differences between the two groups in clinical efficacy and complications.