AIM:To study the effect of mobile microwave on the expression of HSP70 in the lens of rat in vitro.METHODS:HSP70 expression was detected by ELISA and immunohistochemistry after the lenses of rats were cultivated in MEM culture medium.RESULTS:The expression of HSP70 in the mobile microwave groups was significantly higher than the control group(P<0.05).CONCLUSION:Mobile microwave can induce the expression of HSP70 in the lens of rat and cause cataract.