AIM:To investigate the effect of xueshuantong complex capsule and pancreokinin on nonproliferative diabetic retinopathy(NPDR).METHODS:There were 90 patients in our study,randomly divided into xueshuantong complex capsule group,pancreokinin group and combined treatment group.The course of treatment was 12 weeks.Patients’ visual acuity(VA)and ocular fundus were observed before and after drug treatment,the changes were compared.The results of quantitative indicators were dealed with the use of SAS statistical software,any differences in efficacy were analyzed.RESULTS:In this study,xueshuantong complex capsule was applied in the treatment of 30 cases 60 eyes,and effective in 43 eyes with efficiency of 71.6%;pancreokinin in 30 cases 60 eyes,effective in 46 eyes with efficiency of 76.6%;combined treatment in 30 cases 60 eyes,effective in 55 eyes with efficiency of 91.6%.After statistical analysis,application of xueshuantong complex capsule and pancreokinin treatment for NPDR were effective,the two groups showed no differences.Comparison between simple application and joint applications had statistical differences.CONCLUSION:In the early treatment of NPDR,the xueshuantong complex capsule and pancreokinin are valid,their joint applications can offer a better effect.We come to the conclusion that traditional Chinese combined with Western medicine treatment of NPDR is a better way.