AIM:To observe the therapeutic effects of modulated medium frequency electrotherapy(MMFE)and peribulbar injection of mecobalamin for neurogenic extraocular muscles paralysis.METHODS:Ten patients(9 male and 1 female;average age:43.40±7.68 years;the median duration:43.50 days)were treated with MMFE for 20 minutes once a day and peribulbar injection of mecobalamin 500μg every other day,10 days as a course,for 2-4 courses based on patient’s condition;the changes of the position of eye,diplopia and ocular movement recover status were observed.RESULTS:Totally 3 patients were cured with traumatic brain injury,5 patients were improved with brainstem infarction,1 case showed efficacy with traumatic brain injury,1 case was of inefficacy with traumatic brain injury.CONCLUSION:MMFE and peribulbar injection of mecobalamin may improve the neurogenic extraocular muscles paralysis in patients.