AIM:To observe the effect of hyaluronate(HA)eye drops and HA eye drops combined with houttuynia cordata(HC)eye drops on the treatment of dry eye.METHODS:A total of 125 patients 198 eyes with dry eyes were randomly divided into group HA eye drops(group A)(63 cases,100 eyes)and group HA eye drops combined with HC eye drops(group B)(62 cases,98 eyes).The patients were treated with 1g/L HA eye drops in group A and 1g/L HA eye drops combined with HC eye drops in group B.After 2 months’ treatment,clinic symptom,Shirmer I test(S Ⅰ t),break-up time of tear film(BUT),and fluorescence staining(FL)were measured respectively.RESULTS:Both of the two methods could improve the clinic symptom,SⅠ t,BUT,and FL in group B were obviously better than those in group A.CONCLUSION:HA eye drops combined with HC eye drops can improve clinic symptoms of dry eye and heighten the effect of treatment.