AIM:To investigate the therapeutic effect of amniotic membrance transplantation in treament of severe vernal conjunctivitis.METHODS:A total of 9 cases 12 eyes which were vernal conjunctivitis with macropapillary in palpebral conjunctiva and corneal ulcer received amniotic membrane transplantation.Their visual acuity,recurrence in upper palpebral conjunctiva and recovery of corneal ulcer were followed up.RESULTS:Totally 3 cases 5 eyes recurred and were well controlled by local treatment.Visual acuity were increased in all cases during follow-up period.The papilla had not been found in upper lid conjunctiva and cornea was transparent.CONCLUSION:Amniotic membrane transplantation is effective in treatment of severe vernal conjunctivitis with macropapillary in palpebral conjunctiva.