AIM:To evaluate the Clinical effect of triamcinolone acetomide on Graves’ ophthalmopathy.METHODS:Triamcinolone acetomide(40mg)was peri-orbitally injected in all patients.Every 30 days 1 times,4 times were a course of treatment.Visual acuity,eye symptom,exophthalmos,palpebral fissure height and eye position were measured at each visit,the thickness of extraocular muscles was measured by B-mode ultrasonography before treatment and after 6 months.RESULTS:The fifty-six eyes of 30 patients were treated.The average of exophthalmos before and after treatment were 18.2±2.2mm and 14.6±1.8mm(P<0.01),the improved rate of exophthalmia was 84%(47/56);the average height of palpebral fissure were 11.6±1.7mm,8.4±1.1mm(P<0.01),the improved rate was 80%(45/56).The thickness of extraocular muscles:inferior rectus,superior rectus,medial rectus,lateral rectus were 6.25±1.93,4.21±1.25,6.34±1.46,4.17±1.38,5.67±1.64,3.87±1.04,4.57±1.37,3.35±0.81mm respectively,the thickness of the extraocular muscles was significantly reduced.The visual acuity of 28 eyes was improved in the 35 visual acuity decreased eyes.The strabismus and diplopia of 17 patients(74%)disappeared,and 6 patients(26%)were improved in the 23 patients with strabismus and diplopia.No complication was found.CONCLUSION:Triamcinolone acetomide peri-orbital injection can improve the symptom,physical sign and the edema of the extraocular muscles,and side effects are few.