AIM:To evaluate the influence of soft contact lenses with -0.50D lens power on the measured value of the intraocular pressure (IOP) with the non-contact tonometer and Tono-pen tonometer.METHODS: Totally 30 healthy volunteers were included in this study. The right eyes were examined with slit-lamp microscope and there were no scars, edema, ulcers and other pathological changes in the corneas. IOP of the right eyes was measured after topical anesthesia with the non-contact tonometer and Tono-pen tonometer for each of them. After wearing a piece of soft contact lenses with -0.50D power, the IOP values were measured again, and then the IOP values were statistically evaluated. 21 eyes with corneal diseases or ocular hypertension whose IOP could not be measured by the non-contact tonometer were also included in this study. RESULTS: There was no statistical significance between naked eyes and eyes wearing soft contact lenses. The average IOP values measured with non-contact tonometer were 15.25±2.83mmHg in naked eyes and 15.20±2.89mmHg in eyes wearing soft contact lenses (P=0.825). The average IOP values measured with Tono-pen tonometer were 15.93±2.43mmHg in naked eyes and 16.60±3.09mmHg in eyes with soft contact lenses (P=0.146). Fifteen of the 21 eyes got IOP values by the non-contact tonometer after wearing soft contact lenses. The difference was not statistically significant between eyes with or without soft contact lenses.CONCLUSION: Soft contact lenses with -0.50D lens power has no influence on the measurement of IOP with non-contact tonometer and Tono-pen tonometer, indicating that relatively reasonable IOP may be gotten from corneas with scars and ulcers by wearing soft contact lenses. Moreover, it is possible that devices based on contact lens sensor may be used for IOP measurement in the future.