AIM:To investigate retinal nerve fiber layer (RNFL) thickness changes after primary acute angle-closure glaucoma (PAACG). METHODS:Totally 36 patients were recruited, 26 Female (72.2%) and 10 male (27.8%). All the PAACG attacks were resolved after treatment by anti-glaucoma drug followed by laser peripheral iridotomy or surgery. Patients completed RNFL thickness measurement including mean,superior, temporal,inferior and nasal RNFL thickness at 2,4,8,12weeks after resolved using FD-OCT. Analysis of repeated measures and independent-sample t test analysis was carried out to analyze the difference of RNFL thickness (SPSS 15.0). RESULTS:There was no significant difference in RNFL thickness between the attacked eyes and the controled eyes at 2 weeks and 4 weeks. RNFL thickness of all quandrants in the attacked eyes thinned gradually with follow-up, among which there was significant difference between 2 weeks and 4,8,12weeks and there was no significant differences between other weeks. CONCLUSION:After an episode of PAACG, the RNFL thickness is thinning continually mainly in inferior quadrant during the first 8 weeks after primary acute angle-closure glaucoma.