AIM:To compare the difference between conventional refractive procedure and medical refractive procedure in pseudophakic eye, exploring the scientific and standardized procedure of presbyopic refraction for pseudophakic eye. METHODS:Totally 30 age-related cataract patients(60 eyes) were with binocular phacoemulsification and monofocal intraocular lens inter-capsular implantation. All the patients were measured with conventional refractive procedure firstly and then medical refractive procedure after about a week. Presbyopic ADD, accommodative amplitude, negative relative accommodation(NRA) and positive relative accommodation(PRA) with best corrected near visual acuity(BCNVA) and length of comfortable reading time were measured 3 months after surgery. RESULTS:ADD acquired from two refractive procedure was significantly different(P<0.05), ADD acquired from conventional refractive procedure was 1.50±0.42D, which existed positive correlation with age(P<0.05);ADD acquired from medical refractive procedure was 1.28±0.19D, which had no correlation with age(P>0.05). Length of comfortable reading time acquired from medical refractive procedure were 30.13±5.10minutes, which was significantly longer than the length of comfortable reading time acquired from conventional refractive procedure (P<0.05). CONCLUSION:The exact presbyopic refraction for pseudophakic eye should be based on the parameter acquired from medical refractive procedure, in order to achieve longer time and more comfort on reading.