AIM:To investigate, evaluate and analyze the clinical efficacy of vitreoretinal surgery in the treatment of severe corneoscleral laceration. METHODS:From 2009- 03 to 2010- 03 in our hospital, 37 cases (37 eyes) of hospitalized patients with corneoscleral laceration underwent vitrectomy, according to intraoperative conditions combined with silicone oil filling and retinal laser photocoagulation. RESULTS:Post-operative follow-up was 3 to 6(average 5)months with visual acuity, best corrected visual acuity, intraocular pressure and fundus examination, and eye B-ultrasound, OCT and fundus photographic examination for partial affected eyes. Clear vitreous cavity and good retinal reattachment were in 31 cases (31 eyes), among which the number of visual acuity ≥ 0.1 was increased from preoperative 2 eyes to postoperative 11 eyes, visual acuity was improved in 28 cases (28 eyes) at different dagrees, visual acuity remained unchanged in 3 cases (3 eyes) postoperation; 6 cases(6 eyes)without light perception before and after operation underwent eyeball enucleation joint orbital implantation due to postoperative eyeball atrophy. CONCLUSION:Vitrectomy is an effective way for severe corneoscleral laceration. Early surgical treatment may improve postoperative visual function of the affected eyes for most patients with fewer complications.The surgery is safe and effective.