AIM:To compare with the dioptric parameter in diversified myopia before and after Optimized Refractive Keratectomy-Customized Ablation Manager(ORK-CAM)guided aspheric excimer laser·METHODS:Two hundred and fifty patients(500 eyes)who received the ORK-CAM guided aspheric customized excimer laser surgery in 2010 were assigned to two groups(each group of 250 patients)according to the different degree diopter and compared the naked eye vision,mean spherical equivalent,corneal aberration RMS,SphA,Coma and Q value before and 6 months after the surgery.All data were made statistical analysis using SPSS 17.0,P<0.05 was statistically significant·RESULTS: Six months after surgery,there were no statistical differences in naked eye vision(P>0.05)between two groups.Both two groups had lowered spherical equivalent in both absolute value and reduction from baseline(P>0.05).While corneal aberration RMS,SphA,Coma and Q value increased in both groups.Group of high myopia had more increase in these parameters than another group(P<0.05)·CONCLUSION:ORK-CAM guided aspheric customized excimer laser surgery is a safe and effective technique of individualized ablation.But to further reduce the corneal aberration,spherical aberration,coma and Q value increase after high myopia surgery,further exploration is still needed.