AIM：To investigate the curative effect on young people and adults in two different ways of anesthesia after surgical treatment of strabismus and influence on mental health of the patient. METHODS：A retrospective analysis was made on 146 cases in our department from January 2004 to April 2008 who underwent strabismus surgery under local anesthesia alone and 90 cases from July 2008 to July 2011 who underwent strabismus surgery under local anesthesia joint nerve stability to compare the efficacy . RESULTS：After strabismus surgery under local anesthesia alone in 146 cases,correction of eye position was in 134 cases and undercorrection in 10 cases, secondary surgery in 2 cases, there was no case of overcorrection.After local anesthesia combined with nerve stability strabismus surgery in 90 cases, postoperative eye position correction was in 85 cases, undercorrection in 5 cases, there was no case of secondary surgery. CONCLUSION：Strabismus surgery under local anesthesia joint nerve stability may reduce the abnormal performance of eye position in patients caused by mental stress and pain, thereby reduce the probability of secondary surgery, significantly improve the cure rate.