Many eye lesions which can lead to ischemia and anoxia of the related parts and even the formation of new blood vessels has greatly affected the treatment of patients and prognosis.In the study of relevant factors for new blood vessels formation, hypoxia-inducible factor 1(HIF-1) research becomes one of the emerging hot spots, its positive expression in the related lesions and mechanism discussion provides new treatment strategies for clinical treatment.Now the HIF-1 research progresses in the eye related disease are reviewed in this paper.