AIM:To observe the safety and efficacy of phacoemulsification combined with silicone oil removal and intraocular lens implantation on the cataractous eyes filled with silicone oil after vitrectomy. METHODS: Totally 32 patients (32 eyes)with complication of cataract when filled with silicone oil after vitrectomy were selected and operated by phacoemulsification combined with removal of silicone oil through pars plana incision and foldable intraocular lens implantation. And then, they were followed up for 3-18 months (average 9 months). RESULTS:The best-corrected visual acuity after surgery were as follows: 3 eyes were light perception to the counting fingers, 10 eyes were 0.02 to 0.1, 12 eyes were between 0.1 and 0.2, and 7 eyes were above or equal to 0.3. And no complications such as retinal detachment, corneal endothelial decompensation, intraocular lens shifted, silicone oil left and so on were observed. CONCLUSION: The operations of phacoemulsification combined with removal of silicone oil through pars plana incision and foldable intraocular lens implantation, treating complication of cataract in eyes filled with silicone oil after vitrectomy, are safe and effective.