AIM:To investigate the clinical curative effect of artificial lacrimonasal duct interventional therapy in chronic dacryocystitis. METHODS:Sixty-three patients (75 eyes) were involved in this study.Artificial lacrimonasal duct interventional therapy was applied for these patients. RESULTS:Forty-eight patients (76%) were found cured, 7 patients (11%) improved and 2 patients (3%) ineffective in the follow-up period from 0.5-1.5 year. The total effective rate was 87%. CONCLUSION:Artificial lacrimonasal duct interventional therapy is a feasible and reliable therapy for chronic dacryocystitis. It overwhelms the traditional therapies in many aspects.