To investigate the clinical effect of blockage of inferior lacrimal point for the treatment of moderate or severe dry eye syndrome. METHODS: Surgical treatment in blockage of inferior lacrimal point have been used in 19 cases(38 eyes) with moderate or sever dry eye syndrome who have less effect with artifitial tears in our department from January 2010 to January 2011,The height of lacrimal rivus,corneal fluorescein stain,tear film break-up time(BUT),SchirmerⅠtest(SⅠt) were checked by slit-lamp microscope at preoperative 3 days and postoperative 1 week,3 months,6 months. RESULTS:Preoperative dry eye patients complained of dryness, foreign body sensation, visual fatigue. Postoperative patients with these symptoms significantly reduced or even disappeared. Compared with preoperative, 15 cases (30 eyes) with fluorescein staining of corneal epithelial punctate coloring disappeared, and the lower eyelid formed tears River line. Compared with preoperation, BUT and SⅠt significantly increased and the extension. CONCLUSION:Sugery of blockage of inferior lacrimal point can significantly improve the clinical manifestations of dry eye syndrome, increase the tear volume of ocular surface, break the vicious circle of tear secretion, which is an effective and simple method for moderate or severe dry eye patients who can not receive good outcome from medication therapy.