AIM:To investigate the comprehensive treatment of different types of amblyopia in children and evaluate its long-term clinical efficacy. METHODS:Totally 100 cases (190 eyes) were classified by the type of amblyopia, degree of amblyopia, fixation nature, and age, treated with correction of refractive error, occlusion therapy, family fine eyesight training and red light therapy, comprehensive therapeutic apparatus, and followed up over 5 years. RESULTS:Ametropic amblyopia was significantly higher than the anisometropic, strabismic amblyopia and occlusive amblyopia in the curative rate.Mild amblyopia was significantly higher than the moderate and severe amblyopia in the curative rate. Central fixation was higher than the paracentral fixation.The younger treatment of amblyopia, the better efficacy. The 3 to 6-year-old group was significantly higher than other age groups. CONCLUSION:Amblyopia treatment efficacy is closely related to type of amblyopia, degree of amblyopia, fixation nature and age of starting treatment, parents and children compliance. Comprehensive treatment of amblyopia can improve the curative rate and shorten the course of treatment.