AlM：To evaluate the efficacy and safety of photodynamic therapy (PDT) and intravitreal Avastin for choroidal neovascularization (CNV) due to pathologic myopia(PM). METHODS: Seventeen patients(17 eyes) with subfoveal CNV caused by pathologic myopia received PDT followed by an intravitreal injection of 1.5mg Avastin three days later. Verteporfin PDT was performed using the recommended standard. All patients were followed clinically and with fundus flourescein angiography(FFA) and optical coherence tomography(OCT) at baseline and 1 month, 3, 6, 12 months after treatment. The best-corrected visual acuity (BCVA) was measured and the OCT findings were examined before and 1 month, 3, 6, 12 months after treatment. Follow-up time varied from 6 months to 16 months (mean, 10.3 months). The BCVA levels were converted to logMAR equivalents and datas were analyzed using the paired t-test (SPSS 14.0), and P<0.05 was considered statistically significant. RESULTS: At the last visit,the mean BCVA（logMAR）was 1.007±0.103 before treatment and 0.873±0.100 at the last visit (P<0.01). The BCVA improved more than two lines in 4 eyes (23.53%), improved one line in 5 eyes (29.41%) and stabilized (no change) in 8 eyes (47.06%) and none decreased. FFA showed CNV complete closure in 10 eyes (58.82%) , partial closure in 7 eyes (41.18%).The central macular thickness (CMT) on OCT images decreased from 194.67±12.74μm at baseline to 132.07±8.32μm after treatment(P<0.01). No complication occurred. CONCLUSlON: PDT and intravitreal Avastin for CNV caused by PM was effecetive with an significantly improvement in BCVA, FFA and OCT. But visual prognosis was found to be influenced by age at treatment.