There are a number of anti-cicatricial drugs for glaucoma filtration surgery, for example, 5-Fluorouracil(5-FU), mitomycin C(MMC) and so on, but these medicines also have certain complications and side effects. The ophthalmologists are looking for more safe, effective and permanent drugs. In this summary, the author will make the conclusion of these articles published in PubMed from 2009 to 2012 concerning secreted protein acidic and rich in cysteine(SPARC), small interfering RNA(siRNA), Pirfenidone, Sirolimus sustained delivery film, and so on.