AIM:To evaluate the effects of silicone intubation combined with laser by endoscopy for lacrimal duct obstruction. METHODS: Totally 186 patients (238 eyes) with obstruction of lacrimal passage were treated with the above method from May 2008 to June 2010. Tears recovery and fluorescein excretion test were used to determine the lacrimal duct patency. RESULTS: After the mean follow-up for 5.6 months, 214 of the 238 troubled eyes(89.9%) got cured, 20 eyes (84%) turned for better,4 eyes (1.7%) showed no effect. The total effective rate was 98.3%. CONCLUSION:Combination of laser and silicone intubation by endoscopy is a useful, economical and feasible method to treat the obstruction of lacrimal passage.