AIM:To investigate the relationship between the corneal astigmatism and different myopic diopters in 20-29 years-old people in Hubei Province so as to find out the change rule. METHODS:A random sample of 2254 cases of 20-29 years old youth residents in Hubei Province were chosen and the astigmatic diopter, axis and myopic diopter with corneal topography were determined to analyse the change rule. RESULTS: In the 20-29 year-old residents with myopia and astigmatism in Hubei Province, astigmatism with the rule in the three sections of high,moderate,and low myopia were 79.48%, 68.95% and 69.48%, astigmatism against the rule were 20.52%, 31.05% and 30.52% respectively for men; astigmatism with the rule in the three sections of myopia were 80.22%, 75.28%, and 66.92%, astigmatism against the rule were 19.78%, 24.72% and 30.08% respectively for women, indicating a higher proportion of astigmatism with the rule than astigmatism against the rule; the proportion of astigmatism was high in the range of 26 ° -150 °, which were approximately 74.6%, 83.0% and 82.3% respectively in the three sections of myopia for men, showing the proportion in the moderate myopia section the highest, and which were approximately 75.3%, 82.7% and 87.2% respectively in the three sections of myopia for women showing the proportion in the low myopia section the highest ;visible at the same time, the proportion of astigmatism with the rule in the mens moderate myopia section was higher than that in the women’s the same section, while that in the women’s high and low myopia sections was higher than that in the men’s same sections. CONCLUSION: In the 20-29 year-old residents with myopia and astigmatism in Hubei Province, astigmatism occurred in a high proportion within the range of 26 ° to 150 °; the proportion of astigmatism with the rule was higher than that of astigmatism against the rule; the proportion of astigmatism with the rule of women was higher than that of men in the high and low myopia sections,while the proportion of astigmatism with the rule of men was higher than that of women in the moderate myopia section. The differences were statistically significant.