AIM:To investigate the efficacy of interferon alpha-2b(IFN-α-2b)combined ganciclovir on corneal endotheliitis.

METHODS: The 15 cases identified with corneal endotheliitis were treated with periocular injection of IFN-α-2b combined ganciclovir 0.25g one time a day given by intravenous infusion and in conjunction with aciclovir eyedrops every two hours and tobramycin & dexamethasone eyedrops 4 times a day, and continuously treated for 1 week.

RESULTS: All 15 cases were cured and visual acuity improved after 1 week of the above treatment, the cure rate was 100%. In 4-12 months follow-up, there was no recurrent case.

CONCLUSION: IFN-α-2b combined ganciclovir on corneal endotheliitis can get higher cure rate, lower recurrent rate and the treating course is short.