AIM: To investigate the curative effect of Nd:YAG 532nm laser combined with compound anisodine in treatment of branch retinal vein occlusion(BRVO).

METHODS: Totally 130 cases 130 eyes of BRVO were randomly divided into control group and treatment group. The control group was treated by 532nm laser retinal laser photocoagulation, treatment group was treated by 532nm laser retinal photocoagulation combined with compound anisodine with local blocking. Observation of 3 months after treatment in two groups of patients with visual function and the changes of fundus fluorescein angiography(FFA)examination of retinal circulation.

RESULTS: Combined compound anisodine treatment group compared with simple laser treatment control group, the difference was statistically significant in improved visual acuity(P=0.02<0.05). Direct ophthalmoscopy and FFA examination revealed that the retinal hemorrhage absorption, the degree of macular edema reduction, capillary nonperfusion area disappearance, and no new blood vessel formation in the treatment group were better than those in control group.

CONCLUSION: Double frequency Nd:YAG 532nm laser combined with compound anisodine in treatment of BRVO after 3 months, the visual function and FFA was significantly better than that of 532nm laser treatment.