Normal cornea is in stabile angiogenic privilege statement with many factors' effects, which is also the basement for cornea to maintain normal physiology functions. However, angiogenesis forms the pathophysiological basis of some disease. Because the balance between cornea angiogenic and antiangiogenic factors is broken and corneal neovascularization(CNV)switch turned on. CNV usually causes and aggravates corneal clouding and corneal graft rejection. It is one of the reasons leading to blindness. In the recent years, with the development of immunology, molecule biology and pharmacology, there are a lot of break on the cognition of CNV. This review mainly discusses corneal neovascularization mechanism and the therapeutic advance of CNV.