AIM: To discuss the outcome of 100% autologous serum tear usage for persistent corneal epithelial defects of ocular chemical injury.

METHODS: Totally 41 cases(41 eyes)of persistent corneal epithelial defects of ocular chemical injury in our hospital treated with 100% autologous serum were identified and reviewed. The curative effect after the use of 100% autologous serum tear in persistent corneal epithelial defects of ocular chemical injury patients was observed.

RESULTS: The curative effect of acidic ocular chemical injury was better than alkaline ocular chemical injury, with significant difference(χ²=4.120, P=0.042); The curative effect of corneal epithelial defects of small area was better than corneal epithelial defects of large area, with significant difference(χ²=5.857, P=0.016); The curative effect of small range ischemia of conjuntiva and limbus cornea was better than wide range ischemia, with significant difference(χ²=4.137, P=0.042). In 7 invalid cases, 2 cases had undergone conjunctival flap masking operation, 5 cases had undergone amniotic membrane transplantation.

CONCLUSION: The use of 100% autologous serum in persistent corneal epithelial defects of ocular chemical injury is safe and effective. It could accelerate the repair of corneal epithelial defects, reduce complications. It would have a good prospect of clinical application.