AIM:To evaluate the sensitivity and specificity of GDxVCC, short wavelength automated perimetry(SWAP), standard automated perimetry(SAP)indices in the early diagnosis of open angle glaucoma.

METHODS: Forty-two normal subjects(42 eyes), 84 patients with open angle glaucoma(OAG, 84 eyes)were examined with GDxVCC, SWAP and SAP. Receiver's operating characteristic(ROC)curves of RNFL parameters were described and compared. The sensitivity and specificity of GDxVCC, SAP and SWAP on glaucoma diagnosis were calculated.

RESULTS: The area under ROC curve of GDxVCC parameters were: NFI(0.87), IES(0.85), IA(0.80), TSNIT(0.77), SA(0.76)respectively. The sensitivity of GDxVCC, SWAP, SAP were 80.6%, 74.2%, 67.8% respectively, and the specificity were 95.2%, 85.7%, 76.2% respectively.

CONCLUSION: NFI and IES are the best indices to distinguish normal subjects from patients with glaucoma. GDxVCC has the best diagnostic capability, SWAP is the second.