AIM: To obtain information concerning the incidence of infants' ocular disease, and explore the applications of RetCam Ⅱ in the screening of infants' ocular disease.

METHODS: All infants examined with RetCam Ⅱ form September 1, 2011 to September 31, 2012 were enrolled in this study.

RESULTS: Among the 4 860 infants, retinopathy of prematurity(ROP)in 308 cases, retinal hemorrhage in 172 cases; 13 cases of congenital retinal folds; 11 cases of albinism fundus; 10 cases of congenital cataracts; 12 cases of retimoblastoma; persistent hyperplasia of primary vitreous in 9 cases; optic nerve disc dysplasia in 8 cases; congenital choroidal defect in 5 cases; primary pigmentary degeneration of the retina in 4 cases; morning glory syndrome in 4 cases; medullated nerve fibers of retina in 4 cases; congenital macular defect in 3 cases; external exudative retinopathy in 3 cases; familial exudative vitreoretinopathy in 3 cases; nevoid pigmentation of retina in 2 cases; congenital iris dysplasia in 6 cases; optic disc edema in 28 cases; optic atrophy in 15 cases.

CONCLUSION: The infant eye diseases can cause serious harm, and we should pay attention to the early screening, preterm children and term infants with risk factors should be a fundus screening focus groups. RetCam Ⅱ can not only be used in the screening of ROP, but also used in screening of ocular disease for infants and clinical follow-up. Early intervention is of great importance for the prevention and treatment of infants' ocular disease.