AIM: To evaluate effect of polyethylene glycol eye drops combined with basic fiberoblast growth factor(bFGF)eye drops on dry eye.

METHODS: Fifty-one patients(102 eyes)with dry eye were divided into treating group and control group randomly. Both eyes of one were compared by each other. The eyes of treating group were treated by polyethylene glycol eye drops combined with bFGF eye drops 4 times each day for 1 month. The 2 drops were dropped 5 to 10 minutes apart each time. The eyes of control group were treated by polyethylene glycol eye drops 4 times each day for 1month. Schirmer Ⅰ test, break-up time(BUT), corneal fluorescein staining and improvement of symptoms were observed before treatment and after treatment in the two groups.

RESULTS: There was significant difference intear film break-up time(BUT), corneal fluorescein staining and symptoms between before and after the treatment of both groups(P<0.05). There was also significant difference in BUT, corneal fluorescein staining and symptoms between the two groups after the treatment(P<0.05). There was no significant difference in Schirmer Ⅰ test between all time-point of the two groups(P>0.05).

CONCLUSION: Polyethylene glycol eye drops combined with bFGF has obviously effect on dry eye.