Abstract:AIM: To observe the clinical significance of travoprost for prevention of high intraocular pressure(IOP)within 24 hours after diabetic retinopathy(DR)vitrectomy.
METHODS: A total of 102 patients(102 eyes)with DR who underwent vitrectomy and related literatures were analyzed and compared. All patients were randomly assigned to group A(vitrectomy combined with intravitreal silicone oil, C3F8 or balanced salt solution tamponade group, 51 patients 51 eyes)or group B(surgical therapy is the same as the group A, while instilling one drop of 0.04g/L travoprost eyedrops in the inferior cul-de-sac about 60 minutes before the surgery, 51 patients 51 eyes). The changes of IOP, best-corrected visual acuity(BCVA)and ophthalmoscope observations within 24 hours respectively before and after the surgery were counted and analyzed.
RESULTS: The mean IOP of each group within 24 hours after the surgery was higher than the contralateral eyes(t=2.17 and 2.09, P<0.05)and the mean IOP within 24 hours before the surgery(t=2.41 and 2.28, P<0.05). The incidence of high IOP(the high IOP was defined as mean IOP≥25mmHg)and decreased BCVA in group A transcended group B(χ2=4.86 and 3.99,P<0.05). Meanwhile, the mean BCVA of group A within 24 hours after the surgery was slightly worse than that of group B(t=1.43, P>0.05).
CONCLUSION: The preliminary result in our scrutiny showed that the preoperative treatment of 0.04g/L travoprost eyedrops was well tolerated with the significant reduction in the incidence of high IOP and decrease in BCVA within 24 hours after DR vitrectomy. It has clinical significance about the prevention of visual impairment owing to high IOP within 24 hours after DR vitrectomy.
