AIM: To compare the effect of two surgical methods: lacrimal laser combined with mitomycin-C and lead-type silicone tube implantation and lacrimal laser combined with lead-type silicone tube implantation only, for dacryagogatresia treatment.

METHODS: After dacryagogatresia was opened by Nd:YAG laser, 143 cases(150 eyes)in group A underwent lacrimal laser combined with mitomycin-C and lead-type silicone tube implantation. One hundred and forty-three cases(150 eyes)of group B was treated with lacrimal laser combined with lead-type silicone tube implantation only.

RESULTS: In group A, 138 eyes(92.0%)was cured, 10(6.7%)was improved, and the total efficiency was 98.7%, 2 was failed. In group B, 107 eyes(71.3%)was cured, 32(21.3%)was improved, and the total efficiency was 92.7%, 11 was failed. Differences of cure rate(χ²=4.15, P<0.05)and total efficiency(χ²=5.00, P<0.05)between two groups had statistical significance.

CONCLUSION:lacrimal Laser combined with mitomycin-C and lead-type silicone tube implantation is more effective compared with the method of lacrimal laser combined with lead-type silicone tube implantation only.