AIM: To observe the changes of visual functional status at different diopter degrees and to research the correlatively objective sensitive indications among diopter degrees, visual function and morphological damage at early stage in high myopia.

METHODS: Low vision course(LVC)in vision center, macular course(M2, C08, TG2), the index that can reflect the state of visual function in visual electrophysiology system were used to make qualitative and quantitative observation, including single cones-electroretinogram(ERG), 30Hz flicker ERG, P-VEP, 1, 2 rings at first kernel response of multifocal ERG

RESULTS: Vision light sensitivity was decreased with the increase of diopter. P-VEP in visual electrophysiology, single cones cells, b wave of 30Hz flicker ERG, amplitude density of 1 and 2 rings, b wave in 1 ring, and latencies of a, b wave in 2 ring were all decreased(P<0.05). The results of stepwise multiple regression analysis indicated that diopter value had negative correlation with axial and single cone b-wave latency, and had positive correlation with P-VEP amplitude.

CONCLUSION: Vision, visual electrophysiology amplitude can detect the effect of different diopter on retinal function at early stage.