AIM: To study the clinical effect of combined therapy on neonatal dacryocystit of different age groups.

METHODS: The clinical data of 148 eyes of 128 cases with neonatal dacryocystitis were divided into three groups: group 1(<3 months), group 2(aged from 3 months to 6 months), group 3(aged from 6 months to 12 months). Group 1 underwent lacrimal sac massage. Group 2 and group 3 step by step underwent lacrimal sac massage or lacrimal duct pressure flush or probing of lacrimal.

RESULTS: The cure rate of lacrimal sac massage for group 1 was significantly higher than that for group 2(χ²=26.65,P<0.05); Pressure irrigation for group 2 was more effective than that for group 3(χ²=5.23,P<0.05); Probing of lacrimal passage for group 2 was more effective than that for group 3(χ²=3.90,P<0.05).

CONCLUSION: We should choose lacrimal sac massage step by step according to the patient's age, perform lacrimal duct pressure flush, lacrimal duct probing through combined treatment. Lacrimal sac massage seems to be the first treatment for neonatal dacryocystitis patients aged under 3 months. Lacrimal duct pressure flush or probing of lacrimal passage is an effective treatment for neonatal dacryocystitis and the best time for lacrimal duct pressure flush or probing of the lacrimal passage is 3-6 months after birth.